Leading the Invasion

Invasion of waves, invasion of thoughts

Abstract Nowadays, as accepted as the era of information or digital, time has changed and has invited all people to a new world in which everybody must define himself. Avoiding from getting benefit from this human progress is useless; Rather, we must know this great technology best and adapt ourselves with its consequences. In fact, in many countries and among many nations there had been peopl...

The Difference of Expression of 18 Genes in Axillary Invasion and Vascular Invasion Compared to Control Samples in Breast Cancer

Background & Objective: Recent studies from gene profiling have revealed some genes that are overexpressed in the epithelial-mesenchymal transition (EMT) process and are responsible for its initiation and activation resulting in tumor progression and metastasis. The present study aimed to assess the role of genes involved in the EMT process and the association of these genes wi...

Leading The Ignorant: Can Ignorance Eliminate The Free Riding Problem?

AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion

Cell migration is a complex behavior involving many energy-expensive biochemical events that iteratively alter cell shape and location. Mitochondria, the principal producers of cellular ATP, are dynamic organelles that fuse, divide, and relocate to respond to cellular metabolic demands. Using ovarian cancer cells as a model, we show that mitochondria actively infiltrate leading edge lamellipodi...

The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma

The cell's repertoire of transfer RNAs (tRNAs) has been linked to cancer. Recently, the level of the initiator methionine tRNA (tRNAiMet) in stromal fibroblasts has been shown to influence extracellular matrix (ECM) secretion to drive tumour growth and angiogenesis. Here we show that increased tRNAiMet within cancer cells does not influence tumour growth, but drives cell migration and invasion ...